Publications


2016


Flamm AG, Żerko S, Zawadzka-Kazimierczuk A, Koźmiński W, Konrat R, Coudevylle N. 1H, 15N, 13C resonance assignment of human GAP-43. Biomolecular NMR Assignments. 2016 Apr 1;10(1):171-174. doi: 10.1007/s12104-015-9660-9

Cabedo Martinez AI, Weinhaupl K, Lee WK, Wolff NA, Storch B, Żerko S et al. Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17. Journal of Biological Chemistry. 2016 Feb 5;291(6):2917-2930. doi: 10.1074/jbc.M115.685644

Flamm AG, Le Roux AL, Mateos B, Díaz-Lobo M, Storch B, Breuker K et al. N-Lauroylation during the Expression of Recombinant N-Myristoylated Proteins: Implications and Solutions. ChemBioChem: a european journal of chemical biology. 2016 Jan;17(1):82-89. Epub 2015 Dec 3. doi: 10.1002/cbic.201500454

2015


Strotz D, Orts J, Minges M, Vogeli B. The experimental accuracy of the uni-directional exact NOE. Journal of Magnetic Resonance. 2015 Oct;259:32-46. doi: 10.1016/j.jmr.2015.07.007

Chi CN, Vögeli B, Bibow S, Strotz D, Orts J, Güntert P et al. A Structural Ensemble for the Enzyme Cyclophilin Reveals an Orchestrated Mode of Action at Atomic Resolution. Angewandte Chemie (International Edition). 2015 Sept 28;54(40):11657-11661. doi: 10.1002/anie.201503698

Kurzbach D, Kontaxis G, Coudevylle N, Konrat R. NMR Spectroscopic Studies of the Conformational Ensembles of Intrinsically Disordered Proteins. Advances in Experimental Medicine and Biology. 2015 Sept 20;870:149-185. doi: 10.1007/978-3-319-20164-1_5

Wälti MA, Orts J, Vögeli B, Campioni S, Riek R. Solution NMR studies of recombinant Aβ(1-42): from the presence of a micellar entity to residual β-sheet structure in the soluble species. ChemBioChem: a european journal of chemical biology. 2015 Mar 2;16(4):659-669. doi: 10.1002/cbic.201402595

Byrgazov K, Grishkovskaya I, Arenz S, Coudevylle N, Temmel H, Wilson DN et al. Structural basis for the interaction of protein S1 with the Escherichia coli ribosome. Nucleic Acids Research. 2015 Jan;43(1):661-673. Epub 2014 Dec 15. doi: 10.1093/nar/gku1314

2014


Eichmann C, Orts J, Tzitzilonis C, Vogeli B, Smrt S, Lorieau J et al. Intermolecular Detergent-Membrane Protein NOEs for the Characterization of the Dynamics of Membrane Protein-Detergent Complexes. The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 2014 Dec 11;118(49):14288-14301. doi: 10.1021/jp509137q

Vogeli B, Orts J, Strotz D, Chi C, Minges M, Walti MA et al. Towards a true protein movie: A perspective on the potential impact of the ensemble-based structure determination using exact NOEs Dedicated to Prof. Dr. Christian Griesinger. Journal of Magnetic Resonance. 2014 Apr;241(1):53-59. doi: 10.1016/j.jmr.2013.11.016

Softwares

- INPHARMA: In the INPHARMA (Inter-ligands Nuclear Overhauser Effect for Pharmacophore Mapping) method, inter-ligand NOEs are used to derive the relative orientation of small molecular binders that compete for the same receptor site.

- eNORA

- NMR2

Molecular Structures

- NMR2 structure of BRD4-BD2 in complex with iBET-762: 7AQT

- Crystal Structure of HDM2 in complex with Caylin-1: 7QDQ

- Protein allostery of the WW domain at atomic resolution: apo structure: 6SVC

- Protein allostery of the WW domain at atomic resolution: pCdc25C bound structure: 6SVE

- Protein allostery of the WW domain at atomic resolution: FFpSPR bound structure: 6SVH

- Structural ensemble of the enzyme cyclophilin reveals an orchestrated mode of action at atomic resolution: 2N0T

- Crystal Structure of HDM2 in complex with Nutlin-3a: 5C5A

- NMR2 structure of TRIM24-BD in complex with a precursor of IACS-9571: 7B9X

Talks

ANZMAG (invited, plenary session)

Melbourne (2022)

RNA summer School (invited)

CEITEC (2022)

Boehringer Ingelheim (invited)

Vienna (2022)

Workshop on Computer-Aided Drug Discovery (invited)

Graz (2022)

MMCE (invited)

Primošten (2022)

Modern Concepts in Structural Biology (invited)

MFPL (2022)

AUREM (invited), 18th NMR Users Meeting 

Brazil online (2022)

ICMRBS (invited), Emerging Topics in Magnetic Resonance 

International online (2021)

Hunprotexc (invited)

Hungarian online (2021)

Drug Discovery Chemistry (invited), Small Molecules for Immunology, Oncology & COVID

International online (2021)

Lead Generation Strategies (invited)

Boston (2020)

Drug Discovery Chemistry (invited), Fragment-Based Drug Discovery

San Diego (2020)

Philochem AG (invited)

Oltefingen (2019)

Society for Medicines Research (invited)

Cambridge (2019)

Biophysical Approaches to Drug Discovery (invited)

San Diego (2019)

Gordon Research conference: drug design (invited)

Les Diablerets (2019)

University of Guelph (invited)

        Guelph (2019)

University of Basel (invited)

          Basel (2019)

Rhine-Knee Regional Meeting on Structural Biology

Emmetten (2018)

Drug Discovery Chemistry (invited)

San Diego (2018)

ANZMAG (invited)     

  Brisbane (2017)

SMASH (invited)

Baveno (2017)

Fragment Based Lead Discovery

Boston (2016)

AstraZeneca (invited)             

Cambridge (2016)

Structural Biology meets Biophysics

Obernai (2016)

Structural Biology Institute (invited)

Grenoble (2016)

University of Zürich (invited)   

Zürich (2016) 

EUROMAR     

     Aarhus (2016)

Euro Chemistry (invited)     

         Rome (2016)

Zobio (invited)             

Leiden (2016)

NMRS (NMR Society, invited)          

IIT-Kharagpur (2016)

III-Bern 14th International Summer School

  Böningen (2015)

Novartis Institute of Bio-medical research (invited)

 Basel (2014)

EPFL, Laboratory of Bio-NMR           

Lausanne (2014)

EUROMAR     

 Zürich (2014)

XXth Swiss NMR Symposium

Basel (2014)

Masaryk University (invited)   

Brno (2013)

Central European Institute of Technology (CEITEC) (invited)

Brno (2013)

Institut de Génétique et de Biologie Moléculaire et Cellulaire (invited)  

Strasbourg (2010)

EUROMAR (European magnetic resonance)                    

Saint-Petersburg (2008)

FGMR (Fachgruppe Magnetische Resonanzspektroskopie)       

  Göttingen (2007)

 

Julien featured in Drug Discovery Chemistry 2023 Highlights:

https://www.youtube.com/watch?v=CpMvC6GgZIo&t=13s

Grants and Awards

06.2019                      Discussion leader at the Gordon Research Seminars (intl. conference)

07.2015                      Chair at the EUROMAR (intl. NMR conference) in the Bio macromolecules session 

12.2013                      The Innolec prize, Innovation lecture (IC112), Masaryk University Brno 

01.2009-01.2010      PhD Grant, DAAD fellowship, Germany 

01.2007-01.2009      PhD Grant, Fonds der Chemischen IndustrieGermany

12.2007                      Prize Explora’Doc for excellent student, INP, France

09.2005                      Prize Explora’Sup for excellent student, INP, France 

Editorial Activities

Guest editor for the Konrat's Festschrift, a special issue of JMRO dedicated to the 60th birthday of Robert Konrat (to be release soon).