Open positions

Post-doctoral position (3 years, yearly renewable)

A Post-doctoral position is available in the group of Julien Orts at the university of Vienna. The successful candidate will perform cutting edge research in biophysical chemistry using NMR spectroscopy: We want to establish thermodynamic characterization methods of molecular interactions at atomic resolution using solution state NMR. We anticipate that our research will open new avenues in the fundamental understanding of how atomistic mechanisms create function.

The project is part of a larger ERC grant.

The position is available from the 1st of May, 2023, or as soon as possible. 

Profile:

The ideal candidate should hold a Ph.D. in NMR spectroscopy with a background in (Bio)-Physics or Physical Chemistry and have a strong knowledge of biomolecular solution NMR spectroscopy. Proficiency in data science scripting (R, python) is necessary. Knowledge of protein biochemistry is considered a plus. The candidate should be highly motivated, results driven, have high social competencies, excellent communication skills, and be a good team player. 

Working environment:

Our NMR facility has recently been upgraded and houses five NMR spectrometers: 200 MHz, 400 MHz, two 500 MHz, and one 700M Hz with cryo-probes and sampleJet. 

Our wet lab has just been established and is over 200 m² large with state of the art equipment for protein purification and biophysical characterization of protein/ligand interactions.

We offer a stimulating work environment, with research topics ranging from structural biology to drug discovery and scientific collaborations with academic laboratories and companies. Our faculty is young and dynamic: twelve new young Professors were hired in the Department over the last five years.

https://pharmazie.univie.ac.at/divisions/

Website of the group:

bionmr.univie.ac.at

The Department of Pharmaceutical Chemistry is within walking distance of Vienna's historical city center. Vienna is regularly awarded the best city for quality of life and offers a vibrant international community.

https://www.youtube.com/watch?v=mEwISzd1eMc

Applications should be submitted as one PDF file containing a cover letter and your curriculum vitae, with contact details for references. The deadline for applications is March 31^st.Only complete applications will be considered.

For applications or further information please contact:

nicolas.coudevylle@univie.ac.at

Ph.D. position (4 years)

A PhD. position is available in the group of Julien Orts at the university of Vienna. The successful candidate will perform cutting edge research in biophysical chemistry using NMR spectroscopy: We want to establish thermodynamic characterization methods of molecular interactions at atomic resolution using solution state NMR. We anticipate that our research will open new avenues in the fundamental understanding of how atomistic mechanisms create function.

The project is part of a larger ERC grant.

The position is available from the 1st of May, 2023, or as soon as possible. 

Profile:

The ideal candidate should hold a Master's degree and have a strong knowledge of biomolecular solution NMR spectroscopy. Knowledge of protein biochemistry and experience with scripting is considered a plus. You should also have high social competencies, excellent communication skills, and be a good team player. 

. The candidate should be highly motivated, results driven, have high social competencies, excellent communication skills, and be a good team player. 

Working environment:

Our NMR facility has recently been upgraded and houses five NMR spectrometers: 200 MHz, 400 MHz, two 500 MHz, and one 700M Hz with cryo-probes and sampleJet. 

Our wet lab has just been established and is over 200 m² large with state of the art equipment for protein purification and biophysical characterization of protein/ligand interactions.

We offer a stimulating work environment, with research topics ranging from structural biology to drug discovery and scientific collaborations with academic laboratories and companies. Our faculty is young and dynamic: twelve new young Professors were hired in the Department over the last five years.

https://pharmazie.univie.ac.at/divisions/

Website of the group:

bionmr.univie.ac.at

The Department of Pharmaceutical Chemistry is within walking distance of Vienna's historical city center. Vienna is regularly awarded the best city for quality of life and offers a vibrant international community.

https://www.youtube.com/watch?v=mEwISzd1eMc

Applications should be submitted as one PDF file containing a cover letter and your curriculum vitae, with contact details for references. The deadline for applications is March 31^st.Only complete applications will be considered.

For applications or further information please contact:

nicolas.coudevylle@univie.ac.at

We are looking for a highly motivated student to join our group at the Department of Pharmaceutical Sciences.

            The goal of this project is to explore the inhibition of bromodomains as a novel antifungal strategy against invasive Candida infections. Bromodomains are easily druggable, and over the last decade, academic groups and pharmaceutical companies have discovered several inhibitors targeting human bromodomains. In the realm of fungal infection, however, bromodomain targets are largely unexplored. It was recently reported that fungal BET bromodomains are viable anti-fungal targets that could be inhibited without antagonizing human BET function. Our hypothesis is that the functionality of specific fungal bromodomains is critical for the viability and virulence of pathogenic Candida species, and that small molecules targeting these domains with selectivity compared to human BDs represent a potential new class of antifungal drug. 

            Your task will be to express and purify Candida BET proteins in large amounts, high purity and to screen multiple compound libraries against these bromodomains using NMR spectroscopy.

            You should have a deep interested in pharmaceutical sciences as well as in advanced biophysical and spectroscopic technics. We offer extensive training in molecular biology, biochemistry and NMR spectroscopy, a highly collaborative research environment and the possibility to conduct cutting edge research.

For applications or further information please contact:

nicolas.coudevylle@univie.ac.at

We seek an enthusiastic student to join our dynamic and innovative team in the “BioNMR and Drug Discovery by Adva nced NMR Methods” group at the Department of Pharmaceutical Sciences! You will work on an exciting project to explore new approaches in protein–ligand structure determination methods. This is a unique opportunity to make a significant contribution to the field of drug discovery.

We recently proposed NMR² as a powerful method to quickly elucidate protein–ligand complex structures not amenable to crystallography without having to perform the tedious step of protein resonance assignment.

As an intern, your task will be to further develop and explore the capabilities of this method. We will teach you how to analyze sparse NMR data and how to use them in molecular dynamic simulations to solve the structure of therapeutically relevant protein/ligand complexes. You should have a deep interest in advanced biophysical and spectroscopic technics applied to biological problems as well as knowledge in biophysical chemistry and/or computational sciences. This project is planned to be completed in a 6-month period. We offer extensive training in structural biology and advance NMR methods, a highly collaborative research environment and the possibility to conduct cutting edge research.

If you are interested in this position, please send your CV and motivation letter:

Nicolas Coudevylle

Department of Pharmaceutical Chemistry 

Email: nicolas.coudevylle@univie.ac.at

References:

NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24. Torres F et al. J Med Chem. 2022 Apr 14;65(7):5565-5574.

Protein-ligand structure determination with the NMR molecular replacement tool, NMR².
Orts J, Riek R. J Biomol NMR. 2020 Nov;74(10-11):633-642

Website of the group:

bionmr.univie.ac.at

We seek an enthusiastic student to join our dynamic and innovative team in the “BioNMR and Drug Discovery by Advanced NMR Methods” group at the Department of Pharmaceutical Sciences! You will work on an exciting project to explore new approaches in protein–ligand structure determination methods. This is a unique opportunity to make a significant contribution to the field of drug discovery.

You will develop computational technologies for advanced Nuclear Magnetic Resonance (NMR) methods to analyze and predict the molecular interactions between drugs and protein targets. The project lies in computer science, software design, and molecular biophysics interface.

You should have a deep interest in programming (C++ or python) and the will to work with (bio)molecules. The Orts laboratory focuses on structural biology, biophysics, biochemistry, and drug design, within a highly collaborative research environment and the possibility of conducting cutting-edge research.

This project is planned to be completed in a 6-month period. We offer extensive training in structural biology and advance NMR methods, a highly collaborative research environment and the possibility to conduct cutting edge research.

If you are interested in this position, please send your CV and a short motivation letter:

Nicolas Coudevylle

Department of Pharmaceutical Chemistry 

Email: nicolas.coudevylle@univie.ac.at

References:

NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24.
Torres F et al. J Med Chem. 2022 Apr 14;65(7):5565-5574.

Protein-ligand structure determination with the NMR molecular replacement tool, NMR².
Orts J, Riek R. J Biomol NMR. 2020 Nov;74(10-11):633-642

Website of the group:

bionmr.univie.ac.at

We seek a dynamic and enthusiastic student to join the group “BioNMR and Drug Discovery by Advanced NMR Methods” at the Department of Pharmaceutical Sciences. You will have the unique opportunity to conduct your research both at the Department of Pharmaceutical Sciences and the Max Perutz Labs (MPL), collaborating with the group of Sascha Martens. This will provide you with exposure to a wider range of research techniques and environments, as well as the chance to enlarge your network by collaborating with leading researchers in the field.

As an intern, you will have the opportunity to use modern Nuclear Magnetic Resonance (NMR) methods to analyze the molecular functions of proteins during autophagosome formation, which is a fascinating process involving over a dozen proteins with very diverse properties. Despite its importance, little is known about the molecular mechanism by which autophagosomes are formed. This work will shed new light on the enigmatic process.

The techniques that your will learn to express and purify different proteins involved in autophagosome formation, and state-of-the-art NMR methods, which you will employ to study protein interactions in vitro. The results you obtain will be cross-validated by other biophysical methods you will also get the chance to grasp, such as ITC or microscopy-based protein/protein interaction assays (in collaboration with the group of Sascha Martens and the Perutz labs). We offer extensive training in Structural Biology, Molecular Biology,Biochemistry, and Cell Biology, a highly collaborative research environment, and the possibility to conduct cutting edge research.

You should be curious about learning and understanding Biophysical and spectroscopic techniques applied to biological problems. No previous experience is needed, only the basic work you performed during your Praktikum, since we will provide all the needed training. This project is planned to be completed in a 6 month period. 

If you are interested in this position, please send your CV and motivation letter:

Nicolas Coudevylle

Department of Pharmaceutical Chemistry 

Email: nicolas.coudevylle@univie.ac.at

References:

Mechanism of Atg9 recruitment by Atg11 in the cytoplasm-to-vacuole targeting pathway.
Coudevylle N et al. J Biol Chem. 2022 Feb;298(2):101573.

Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation.
Sawa-Makarska J, Baumann V, Coudevylle N et al. Nat Commun. 2020 Sep 4;369(6508).

Website of the group:

bionmr.univie.ac.at            You should have a deep interested in pharmaceutical sciences as well as in advanced biophysical and spectroscopic technics. We offer extensive training in molecular biology, biochemistry and NMR spectroscopy, a highly collaborative research environment and the possibility to conduct cutting edge research.

For applications or further information please contact:

nicolas.coudevylle@univie.ac.at